| ___________________________________________________________ |
| Thursday, Oct. 28 |
| 09:00 > 09:30 |
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OPENING CEREMONY AND WELCOME ADDRESS
Chairs: Hans Ulrich Haering (Tubingen, DE)
and Francesco Bèguinot (Naples, IT)
Welcome address of the President and the Organizer.
Ulf Smith (Gothenburg, SE)
Welcome address of the President of the European
Association for the Study of Diabetes
Gabriele Riccardi (Naples, IT)
Welcome address of the President of the Italian Diabetes Society.
Gaetano Lombardi (Naples, IT)
Welcome address of the President of the Italian Endocrinology Society.
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| 09:30 > 10:30 |
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MEETING INTRODUCTION
Insulin action in 2010: perspectives in the coming decade.
Chairs: Edwin Gale (Bristol, UK) & Jesse Roth (Whitestone, NY USA)
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09:30 > 09:50 |
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Jesse Roth (Whitestone, NY USA)
Introduction: Paired Revolutions in Intercellular Communication: The Tenth Day of Creation |
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09:50 > 10:10 |
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Lecture 01 - C.Ronald Kahn (Boston, NY USA)
Continuing evolution in our concepts of insulin action and insulin resistance |
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10:10 > 10:30 |
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Lecture 02 - Ulf Smith (Gothenburg, SE)
Understanding insulin signaling and action-also a future challenge |
| 10:30 > 11:00 |
 |
Coffee break |
| 11:00 > 12:30 |
 |
ORAL SESSION 01
New concepts in insulin signal transduction.
Chairs:
Masato Kasuga (Tokio, JP) & Emmanuel Van Obberghen (Nice, FR) |
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11:00 > 11:30 |
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Lecture 03 - Domenico Accili (New York, NY USA)
Unusual sites of insulin resistance |
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11:30 > 12:00 |
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Lecture 04 - Takashi Kadowaki (Tokio, JP)
Adipocyte control of insulin action |
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12:00 > 12:15 |
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Oral Presentation 1 (C1-1) - Qiong L. Zhou
A novel protein enhances insulin-stimulated akt phosphorylation and glut4 translocation in adipocytes |
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12:15 > 12:30 |
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Oral Presentation 2 (C1-2) - Barbara Salani
IGF-IR internalizes with caveolin-1 and ptrf/cavin in hacat cells |
| 12:30 > 14:30 |
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POSTER SESSION 01 & Buffet lunch |
| 14:30 > 15:30 |
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ORAL SESSION 02
The role of adipose tissue in insulin action
Chairs: Eddy Karnieli (Haifa, IL) & Francesco Purrello (Catania, IT) |
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14:30 > 15:00 |
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Lecture 05 - Francesco Giorgino (Bari, IT)
The biological specificity of visceral fat
With the Unrestricted Educational Grant of Eli Lilly Italia |
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15:00 > 15:15 |
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Oral Presentation 3 (C2-3) - Karin Stenkula
Insulin regulates the spatial distribution of glucose transporter-4 on the cell surface |
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15:15 > 15:30 |
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Oral Presentation 4 (C1-4) - Gregory Raciti
ANKRD26 gene ablation causes diabetes in mice |
| 15:30 > 16:00 |
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Coffee break |
| 16:00 > 17:00 |
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ORAL SESSION 03
Insulin signalling in peripheral tissues
Chairs:
Amira Klip (Toronto, CA) & Robert J. Smith (Providence, RI USA) |
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16:00 > 16:30 |
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Lecture 06 - Timothy E. McGraw (New York, NY USA)
AKT2 regulation of GLUT4 trafficking. |
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16:30 > 16:45 |
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Oral Presentation 5 (C3-5) - Isabelle Castan-Laurell
Chronic apelin treatment in HFD-fed mice improves b-oxydation and insulin resistance |
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16:45 > 17:00 |
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Oral Presentation 6 (C3-6) - Kurt Højlund
Is defect insulin signaling to mitochondria linked to insulin resistance in human muscle? |
| 17:00 - 17:10 |
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Francesco Beguinot (Naples, IT) - The past, the present and the future of the IR meeting community. |
| 17:10 > 17:55 |
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ORAL SESSION 04
Insulin action in obesity
ROBERTO DE PIRRO MEMORIAL CERIMONY
Chairs: Samuel Cushman (Bethesda, MD, USA) & Ulf Smith (Gothenburg, SE) |
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17:10 > 17:40 |
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Lecture 07 - Hadi Al-Hasani (Nuthetal, DE)
Roberto De Pirro Memorial Lecture - Obesity genes and their impact on insulin action: lesson from mouse genetics.
With the Unrestricted Educational Grant of Sanofi Aventis |
| |
17:40 > 17:55 |
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Oral Presentation 6bis (C4-6bis) - Paul Pilch
Adiporedoxin, an adipocyte-enriched novel regulator of adiponectin assembly/secretion
Talk not included in the CME program |
| 19:30 > |
|
Dinner |
| ___________________________________________________________ |
| Friday, Oct. 29 |
| 08:30 > 10:00 |
|
ORAL SESSION 05
Genetic and epigenetic control of insulin action
Chairs:
Henning Beck-Nielsen (Odense, DK) & Michael P. Czech (Worcester, MA USA) |
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08:30 > 09:00 |
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Lecture 08 - Markku Laakso (Kuopio, FI)
Human gene variation affecting insulin action and secretion |
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09:00 > 09:30 |
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Lecture 09 - I. Karen Temple (Southampton, UK)
Epigenetics and diabetes: lesson from neonatal diabetes and disorders of imprinting |
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09:30 > 09:45 |
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Oral Presentation 7 (C4-7) - Raffaele Teperino
Environmental and epigenetic regualation of the diabetes -related PED/PEA-15 gene |
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09:45 > 10:00 |
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Oral Presentation 8 (C4-8) - Syephan Scherneck
ZFP69 as a potential modulator of obesity-associated diabetes |
| 10:00 > 10:30 |
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Coffee break |
| 10:30 > 12:00 |
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ORAL SESSION 06
Environmental control of insulin action and nutrient metabolism
Chairs:
Angelika Bierhaus (Heidelberg, DE) & Philipp Gorden (Bethesda, MD USA) |
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10:30 > 11:00 |
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Lecture 10 - Juleen Zierath (Stockholm, SE)
Metabolic regulation in diabetes through DNA methylation. |
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11:00 > 11:30 |
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Lecture 11 - Christopher B. Newgard (Dhuram, NC USA)
Metabolic drivers of insulin resistance and related disorders |
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11:30 > 11:45 |
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Oral Presentation 9 (C5-9) - Katy Raddatz
Pkc epsilon regualtes hepatic lipid metabolism during short term lipid oversupply |
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11:45 > 12:00 |
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Oral Presentation 10 (C5-10) - Assaf Rudich
Activation of ASK1 in omental fat links adipocyte stress to whole-body insulin resistance |
| 12:00 > 14:00 |
 |
POSTER SESSION 02 & Buffet Lunch |
| 14:00 > 15:30 |
|
ORAL SESSION 07
β- and α-cells in insulin-resistance states
Chairs: Jean-Louis Carpentier (Geneve, CH) & Piero Marchetti (Pisa, IT) |
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14:00 > 14:30 |
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Lecture 12 - Bernard Thorens (Lousanne, CH)
IGF-2 and IGF-1 receptor in the control of β-cell mass and function |
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14:30 > 15:00 |
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Lecture 13 - Rohit N. Kulkarni (Boston, MA USA)
Intra-islet insulin signalling regulates α-cell function in vivo |
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15:00 > 15:15 |
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Oral Presentation 11 (C6-11) - Eugenia Tiziana Maniscalchi
MAPK activation in alpha TC1 cells after chronic palmitate exposure |
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15:15 > 15:30 |
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Oral Presentation 12 (C6-12) - Avital Beck
Sirna screening for genes involved cytokine-induced pancreatic beta cell death |
| 15:30 > 16:00 |
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Coffee break |
| 16:00 > 17:30 |
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ORAL SESSION 08
Insulin action in the CNS
Chairs: Ira D. Goldfine (San Francisco, CA, USA) & Giuseppe Paolisso (Naples, IT) |
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16:00 > 16:30 |
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Lecture 14 - Jens C. Brüning (Köln, DE)
Central regulation of energy metabolism by insulin |
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16:30 > 17:00 |
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Lecture 15 - Suzanne Craft (Seattle, WA USA)
Insulin-resistance and neurodegeneration: novel mechanisms and therapeutic implications |
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17:00 > 17:15 |
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Oral Presentation 13 (C7-13) - Toshiyasu Sasaoka
Impact of the elevation of lipid phosphatase ship2 on brain insulin action for the cognitive function in mice |
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17:15 > 17:30 |
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Oral Presentation 14 (C7-14) - Tina Sartorius
Toll-like receptor2/4 deficiency protects from diet-induced brain insulin resistance |
| 19:00 > |
|
Meeting Point for Gala Dinner |
| ___________________________________________________________ |
| Saturday, Oct. 30 |
| 09:30 > 10:45 |
|
ORAL SESSION 09
Metabolism and cancer
Chairs: Pietro Formisano (Naples, IT) & Derek Le Roith (New York, NY USA) |
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09:30 > 10:00 |
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Lecture 16 - Reuben J. Shaw (La Jolla, CA USA)
AMPK signaling in glucose metabolism and growth control |
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10:00 > 10:30 |
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Lecture 17 - Michael Pollak (Montreal, CA)
Insulin signalling and metformin in relation to cancer: new developments
With Unrestricted Educational Grant of Sanofi Aventis |
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10:30 > 10:45 |
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Oral Presentation 15 (C8-15) - Jutta Nagel
Glargine and NPH insulin similary increase colonic cell proliferation and ACF formation |
| 10:45 > 11:15 |
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Coffee break |
| 11:15 > 12:30 |
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ORAL SESSION 10
Insulin-action and cancer
Session not included in the CME program
Chairs: Ira Pastan (Bethesda, MD USA) & Riccardo Vigneri (Catania, IT) |
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11:15 > 11:45 |
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Lecture 18 - Morris F. White (Boston, MA USA)
The dark side of IRS-2: cancer and neurodegeneration |
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11:45 > 12:15 |
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Lecture 19 - Norbert Tennagels (Frankfurt, DE)
Metabolic and mitogenic signalling of exogenus insulin(s) |
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12:15 > 12:30 |
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Oral Presentation 16 (C9-16) - Michael Greene
Breast cancer growth and activation of insulin/IGF-1 signaling by circadian disruption |
| 12:30 > 14:30 |
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POSTER SESSION 03 & Buffet Lunch |
| 14:30 > 16:30 |
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ORAL SESSION 11
Future strategies for treating diabetes
Chairs: Stefano Del Prato (Pisa, IT) & Giorgio Sesti (Catanzaro, IT) |
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14:30 > 15:00 |
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Lecture 20 - Fatima Bosch (barcelona, ES)
Gene therapy in diabetes |
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15:00 > 15:30 |
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Lecture 21 - Markus Stoffel (Zürich, CH)
MicroRNAs: regulators of metabolism and therapeutic targets |
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15:30 > 15:45 |
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Oral Presentation 17 (C10-17) - Lucie Popineau
GRB14 inhibition in mouse liver improves glucose tolerance and hepatic steatosis |
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15:45 > 16:00 |
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Oral Presentation 18 (C10-18) - Olivier Bezy
PKCdelta is a regulator of hepatic insulin sensitivity and modifies hepatosteatosis risk |
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16:00 > 16:15 |
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Oral Presentation 19 (C10-19) - Shiri Karni Ahkenazi
NFKB paradox: suppression of glut4 expression with concomitant tranlocation enhancement |
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16:15 > 16:30 |
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Oral Presentation 20 (C10-20) - Mashito Sakai
Cited2 regulates hepatic gluconeogenesis by controlling PGC-1alpha activity |
| 16:30 > 17:00 |
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Coffee break |
| 17:00 > 18:30 |
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ORAL SESSION 12
Diabetes Complications
Chairs: Michele Muggeo (Verona, IT) & Yehiel Zick (Rehovot, IL) |
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17:00 > 17:15 |
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Oral Presentation 21 (C11-21) - E. Dale Abel
Insulin signaling is a physiological regulator of myocardial autophagy in vivo |
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17:15 > 17:30 |
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Oral Presentation 22 (C11-22) - Rossella Menghini
Increased expression of TIMP3 protects against diabetes and atherosclerosis |
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17:30 > 17:45 |
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Oral Presentation 23 (C11-23) - Janice Zabolotny
Protein tyrosine phosphatase 1b (PTP1B) regulates wound healing |
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17:45 > 18:00 |
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Oral Presentation 24 (C11-24) - Eugenia Carvalho
Immunosuppressive agents alter glucose metabolism, blood pressure and heart rate in rats |
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18:00 > 18:30 |
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Lecture 22 - Hans Ulrich Haering (Tübingen, DE)
President lecture - Insulin action in human brain |
| 18:30 > 19:00 |
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CONCLUSION CEREMONY |
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18:30 > 18:45 |
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Francesco Bèguinot (Naples, IT)
Conclusion remarks |
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18:45 > 19:00 |
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XII meeting announcement |
| 19:00 > |
|
Farewell Cocktail |
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